Nanobotmodels create realistic prion propagation illustration

Posted by | August 09, 2013 | Uncategorized | No Comments
Prion disease

Nanobotmodels visualization studio creates education illustration of prion propagation mechanism.

Prion propagation illustration

(click on this illustration to reach it HD version 1920×1080 pix)

Prion is the microscopic protein particle similar to a virus but lacking nucleic acid, thought to be the infectious agent responsible for scrapie and certain other degenerative diseases of the nervous system.

Prions propagate by transmitting a misfolded protein state. If a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the disease-associated, prion form; the prion acts as a template to guide the misfolding of more proteins into prion form. These newly formed prions can then go on to convert more proteins themselves; this triggers a chain reaction that produces large amounts of the prion form. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets.

The transmissible agent of prion disease consists of prion protein (PrP) in β-sheet-rich state (PrPSc) that can replicate its conformation according to a template-assisted mechanism. This mechanism postulates that the folding pattern of a newly recruited polypeptide accurately reproduces that of the PrPSc template.

Prion molecules are found at the cell surface, where they are anchored to the nerve cell membrane by short fatty acid molecules called glycosylphosphatidylinositols (GPIs), which are attached to the prions following synthesis of the proteins. Prions are, therefore, most likely to play a role (or roles) in some aspect of the cell-to-cell signalling process.

This illustration is the first step to full-length animation covering all prion transmitting mechanism – from delivery inside neuron until forming amyloid strands. This animation will be available this fall.

Nanobotmodels was established in 2007 with the goal of developing highly innovative, digital graphics to depict actual and conceptual technologies via the synergistic fusion of art and science. The still nascent, yet prospectively powerful discipline of nanotechnology is poised to radically transform medicine, engineering, biotechnology, electronics and myriad other sectors in the relative near-term. Hence, visionary artistic renderings that portray various aspects of this exciting nanofuture will be beneficial in facilitating a clear understanding of its fundamental concepts to a broad demographic.

Nanobotmodels generates imaginative and engaging state-of-the-art nanotechnology and nanomedical illustrations and animations. Any prototypical component, device, system or far flung concept that might be conceived of can be translated into captivating and colorful photorealistic animated or static renderings and presentation materials…. We bring them all to life for you!

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